Parkin promotes intracellular A 1-42 clearance
نویسندگان
چکیده
منابع مشابه
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin. Here we report a novel pathway for mitochondrial elimination, in which these organelles undergo Parkin-dependent sequestration into Rab5-positive ear...
متن کاملParkin promotes cell survival via linear ubiquitination.
Mitochondrial dysfunction has been linked to the pathogenesis of Parkinson’s disease (PD). PD-associated mutants of Parkin show defects in mitophagy, suggesting that Parkin exerts its neuroprotective role by removal of damaged mitochondria. Müller-Rischart et al (2013) now uncover an autophagy-independent pathway involving Parkin-mediated activation of the LUBAC ubiquitin ligase to prevent mito...
متن کاملTyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin-1 interaction, while peripheral administration of TKIs, including Nilotinib and Bosutinib, incre...
متن کاملUbiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance
Parkinson's disease (PD) is a movement disorder associated with genetic and age related causes. Although autosomal recessive early onset PD linked to parkin mutations does not exhibit α-Synuclein accumulation, while autosomal dominant and sporadic PD manifest with α-Synuclein inclusions, loss of dopaminergic substantia nigra neurons is a common denominator in PD. Here we show that decreased par...
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Pulmonary complications often involve a modulation of innate immune responses [11–19] , and many studies have shown that surfactant proteins play a critical role in these processes [review in 20 ]. In this issue, Sylvia Ujma et al. [21] present an excellent review article, describing surfactant proteins A and B as being expressed also in many other parts of the body, such as the reproductive, u...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2009
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddp258